AB0003 HLA-ALLELES IN SUSCEPTIBILITY TO SYSTEMIC AND OLIGOARTICULAR JUVENILE IDIOPATHIC ARTHRITIS IN THE BELARUSIAN POPULATION

Background: Juvenile idiopathic arthritis (JIA) is a complex trait, the most common rheumatic disease in children. Considering clinical heterogeneity of disease, genetic background particular JIA subtypes may also vary significantly. Objectives: This work was aimed to reveal characteristic patterns HLA associations within 11 loci for two clinically different forms Belarusian population. Methods: 24 patients diagnosed with systemic JIA, oligoarticular and healthy controls were included into study. The divided subgroups according IIAR classification criteria. High-throughput typing performed using TruSight v2 Sequencing Panel (Illumina) on MiSeq system. Sample analysis Assign v2.0 software. Results: DQA1* 05:01:01 DQB1* 02:01:01 alleles showed protective effect against both (p = 0.007; OR=0.08; 95% CI=[0.009–0.65] p 0.01; OR=0.09; CI=[0.01–0.83]) oliarticular 0.026; OR=0.16; CI=[0.03–0.79] 0.046; OR=0.2; CI=[0.04–1.00], while DRB1 *03:01 negative association revealed only 0.03; OR=0.11; CI=[0.01–0.88]). At same time 04:02:01 (p=0.026; OR=5.88; CI=[1.20–28.72]) DRB1* 08:01:01 (p=0.07; OR=3.94; CI=[1.01–15.39]) allele frequencies significantly higher oligoarthritis but not when compared controls. Conclusion: distinct HLA-alleles associated population as well some oligoartricular JIA. Disclosure Interests: None declared